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FLASH GENE
Symbol WNT5A contributors: shn/ - updated : 27-01-2016
HGNC name wingless-type MMTV integration site family, member 5A
HGNC id 12784
ASSOCIATED DISORDERS
corresponding disease(s) RBNS2
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
aberrantly methylated from the early stages of colorectal cancers
tumoral       loss of function
inactivated by aberrant methylation in acute lymphoblastic leukaemia
tumoral     --over  
by hypomethylation in prostate cancer
tumoral     --low  
in epithelial ovarian cancer
tumoral     --over  
in melanoma and is thought to be a critical regulator of cell movement during metastasis
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancer  
WNT5A-ROR2 signaling can be a target of cancer therapies to prevent cancer cells from undergoing invasion and metastasis
cancerreproductiveovary
by reconstituting WNT5A signaling may offer an effective new strategy for EOC therapy
ANIMAL & CELL MODELS
  • Wnt5a-/- mice exhibit dwarfism, facial abnormalities, short limbs and tails, dysplasia of lungs and genitals, and ventricular septal defects
  • Wnt5a-/- mice display a defect in (mid)brain morphogenesis, including an impairment in midbrain elongation and a rounded ventricular cavity