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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

HES1

contributors: mct/npt/pgu - updated : 04-04-2016

HGNC name	hairy and enhancer of split 1, (Drosophila)
HGNC id	5192

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	may represent a biomarker for prediction of patients with poor prognosis in hepatocellular carcinoma
Therapy target
	System Type Disorder Pubmed osteoarticular bone ostéoporosis targeted down-regulation of Hes1 expression or activity in osteoblasts could be considered as a possible strategy in the development of novel therapies for osteoporosis

ANIMAL & CELL MODELS

Hes1 homozygous null mutant mice displayed a neural tube closure defect, and exencephaly was induced at the mid/hindbrain boundary