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FLASH GENE

Symbol

MANF

contributors: mct/npt/pgu - updated : 04-06-2015

HGNC name	mesencephalic astrocyte-derived neurotrophic factor
HGNC id	15461

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral somatic mutation       in renal cell carcinoma tumoral somatic mutation       squamous cell carcinoma of the head and neck, lung, breast, pancreas and prostate carcinomas constitutional     --over   in the early stage of cerebral ischemia constitutional       gain of function by endoplasmic reticulum (ER) stress

Susceptibility

Variant & Polymorphism

Candidate gene	specifically promotes beta cell proliferation and survival, thereby constituting a therapeutic candidate for beta cell protection and regeneration
Marker
Therapy target
	System Type Disorder Pubmed neurology neurodegenerative Parkinson/dementia Parkinsonism selective, neuroprotective effect of MANF for dopaminergic neurons suggests that it may be indicated for the treatment of Parkinson disease

ANIMAL & CELL MODELS

Manf-deficient mice that strikingly develop severe diabetes due to progressive postnatal reduction of beta cell mass, caused by decreased proliferation and increased apoptosis