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FLASH GENE

Symbol

APPL2

contributors: mct - updated : 17-05-2017

HGNC name	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
HGNC id	18242

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   translocation     chromosomal aberration involving DIP13B in DEL22Q13 syndrome, translocation t(12;22)(q24.1;q13.3) with SHANK3/PSAP2 tumoral     --over   in aggressive prostate cancer tissues

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	APPL, APPL2-TGFBR1 complex may serve as a prognostic marker, in prostate cancer
Therapy target

ANIMAL & CELL MODELS