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FLASH GENE
Symbol ERBB4 contributors: mct - updated : 03-10-2015
HGNC name v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
HGNC id 3432
ASSOCIATED DISORDERS
corresponding disease(s) ALS19
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral germinal mutation      
juxtamembrane splice variants in same chidhood medulloblastoma
tumoral     --over  
in lung carcinoma
tumoral somatic mutation      
in melanoma
Susceptibility
  • to schizophrenia
  • to left ventricular outflow tract (LVOT) defects
  • Variant & Polymorphism other
  • interaction between variants in NRG1 and ERBB4 might contribute to susceptibility for schizophrenia
  • a specific haplotype in intron 3 of ERBB4 positively associated with the combined LVOT defects phenotype
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerskin 
    targeting of ERBB4 with small-molecule inhibitors should be considered as a therapeutic approach for the many individuals with melanoma
    ANIMAL & CELL MODELS
    astrogenesis occurs precociously in ErbB4 knock-out mice