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FLASH GENE
Symbol CD86 contributors: mct - updated : 24-10-2017
HGNC name CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)
HGNC id 1705
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional       gain of function
or expressed aberrantly on immune cells in a wide array of autoimmune and infectious diseases
constitutional     --low  
of CD86 expression by transitional B-cells due to the autocrine effect of IL10, which in turn leads to decreased T-cell proliferation and TNF production
Susceptibility to asthma
Variant & Polymorphism other I179V polymorphism, may be a novel aetiological factor in the development of asthma and related allergic disorders
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS