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FLASH GENE

Symbol

FHIT

contributors: SGE/npt - updated : 16-03-2010

HGNC name	fragile histidine triad gene
HGNC id	3701

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       loss of function in colorectal adenomas and in testicular germ cell tumor with metastasis tumoral fusion       with TRC8 in the translocation t(3;8) associated with clear cell renal carcinoma constitutional   LOH     in patients with idiopathic pulmonary fibrosis without lung carcinoma tumoral   translocation     t(3;20) (p14;p20) in breast cancer tumoral       loss of function in periocular sebaceous gland carcinomas

Susceptibility

to Muir-Torr syndrome to autism spectrum disorder to breakage that could contribute to lung carcinogenesis (increased by active cigarette smoking)

Variant & Polymorphism other	de novo copy number variant in autism spectrum disorder

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS