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FLASH GENE
Symbol LHX6 contributors: mct - updated : 07-07-2015
HGNC name LIM homeobox 6
HGNC id 21735
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
by hypermethylation in head and neck squamous cell carcinoma and colon carcinoma
constitutional     --low  
in schizophrenia
tumoral     --low  
by hypermethylation in lung cancer
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • amelogenin and ameloblastin expression is reduced and/or delayed in the Lhx6 null mice, potentially resulting from defects in dentin deposition and ameloblast differentiation