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FLASH GENE
Symbol SMYD2 contributors: mct/npt/pgu - updated : 07-11-2018
HGNC name SET and MYND domain containing 2
HGNC id 20982
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional       loss of function
results in the loss of HSP90AA1 methylation, impaired titin stability, and altered muscle function
constitutional     --low  
by promoter DNA methylation is associated with abdominal aortic aneurysm (AAA)
tumoral     --over  
at significantly higher levels in breast cancer cell lines and in breast tumor tissues
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerdigestiveoesophagus
prognosticator and potential therapeutic target in esophageal squamous cell carcinoma
cancerdigestivepancreas
inhibition of SMYD2 cooperates with standard chemotherapy to treat PDAC cells and tumors
ANIMAL & CELL MODELS
  • Smyd2 deficiency delayed renal cyst growth in postnatal kidneys from Pkd1 mutant mice