Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

ASXL1

contributors: mct - updated : 29-11-2016

HGNC name	additional sex combs like 1 (Drosophila)
HGNC id	18318

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

BOPS

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       with PAX5, in t(9;20)(p11-13;q11) in patients with acute lymphoblastic leukemia tumoral   deletion     with high frequencies in multiple forms of myeloid malignancies, and its alterations are associated with poor prognosis tumoral somatic mutation       associated with CSF3R and/or SETBP1 mutation in chronic neutrophilic leukemia (CNL)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	Asxl1 knockout mice exhibit defects in frequency of differentiation of lymphoid and myeloid progenitors, but not in multipotent progenitors
	Asxl1 deletion in mice led to developmental abnormalities including dwarfism, anophthalmia, and 80% embryonic lethality