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FLASH GENE

Symbol

PERP

contributors: shn - updated : 05-03-2019

HGNC name	PERP, TP53 apoptosis effector
HGNC id	17637

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in the metastating mammary carcinoma and pancreas cell lines

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	Perp-/- mice die postnatally, with dramatic blistering in stratified epithelia symptomatic of compromised adhesion (
	Perp-null mice display dramatic enamel defects due to the detachment of ameloblasts from the stratum intermedium (