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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

METTL3

contributors: mct - updated : 05-11-2019

HGNC name	methyltransferase like 3
HGNC id	17563

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function significantly augments calcium deposition and enhances alkaline phosphatase activity of mesenchymal stem cells, uncovering an inhibitory role of METTL3 in osteogenesis tumoral       gain of function in gastric cancer constitutional   deletion     of METTL3 from the adult haematopoietic system led to an accumulation of Haematopoietic stem cells (HSCs) in the bone marrow and a marked reduction of reconstitution potential due to a blockage of HSC differentiation constitutional         silencing METTL3 could sustain long-chain fatty acids (LCFAs) absorption through blocking the TRAF6-dependent inflammation response tumoral     --over   in lung adenocarcinoma tumoral     --low   of METTL3 and METTL14 expressions in childhood ETV6/RUNX1-positive acute lymphoblastic leukemia tumoral     --over   in cervical tumor tissues

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	elevated METTL3 level was predictive of poor prognosis in gastric cancer
Therapy target
	System Type Disorder Pubmed cancer head and neck   METTL3 might be a potential target for cervical cancer therapy

ANIMAL & CELL MODELS

Mettl3 overexpression in MSCs protects the mice from estrogen deficiency-induced osteoporosis