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FLASH GENE

Symbol

FANCL

contributors: mct - updated : 19-09-2016

HGNC name	Fanconi anemia, complementation group L
HGNC id	20748

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

FANCL

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   by hypermethylation of promoter regions in sporadic acute leukaemia constitutional     --other   suppression of FANCL expression in normal human CD34(+) stem and progenitor cells results in fewer CTNNB active cells and inhibits expansion of multilineage progenitors

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS