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FLASH GENE
Symbol FOXA1 contributors: mct - updated : 25-03-2017
HGNC name forkhead box A1
HGNC id 5021
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in esophageal squamous cell carcinoma and in breast cancer
tumoral     --low  
is associated with better survival in the breast cancer
constitutional       gain of function
in both replicative and oncogene-induced senescence, and in turn activates transcription of CDKN2A through multiple mechanisms (
tumoral somatic mutation      
in prostate cancer
Susceptibility to breast cancer
Variant & Polymorphism SNP
  • many of the SNPs associated with breast cancer risk may be modulating the same biological process, namely, DNA affinity for FOXA1, a key regulator of ER activity
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    target fo breast cancer
    diabete  
    could be a novel therapeutic target for insulin resistance
    digestiveliver 
    could be a novel therapeutic target for nonalcoholic fatty liver disease
    ANIMAL & CELL MODELS