| kindlin-3-deficient mice develop severe osteopetrosis because of profound adhesion and spreading defects in bone-resorbing osteoclasts | |
mice lacking Kindlin-3 in T cells were immunized with an autoantigen to induce experimental autoimmune encephalitis (EAE), a model of multiple sclerosis, and autoreactive Kindlin-3–null T cells extravasate only when the brain microvasculature expresses high integrin ligand levels |
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kindlin-3-null mice, which die perinatally of severe bleeding and leukocyte adhesion deficiency, mice expressing as little as 5p100 of kindlin-3 were viable and protected from spontaneous bleeding and infections |
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