Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

IKBKE

contributors: mct/shn - updated : 19-01-2022

HGNC name	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
HGNC id	14552

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   amplification --over   in breast cancer cell lines and patient-derived tumors tumoral     --over   in breast cancer, ovarian cancer and prostate cancer tumoral     --over   in glioma and contributes to resistance of glioma cells to apoptosis via activating NFKB constitutional     --low   in SLE patients compared with healthy controls

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	a possible therapeutic target for obesity, insulin resistance and diabetes
	System Type Disorder Pubmed cancer     therapeutic target for cancer intervention miscelleaneous pain   may be useful as a therapeutic target in the treatment of inflammatory pain cancer     MCCK1 is an IKBKE inhibitor with anti-tumor activity and could be a potential anti-cancer agent for patients with tumors over expressing IKBKE

ANIMAL & CELL MODELS

mice lacking IKKepsilon produce normal amounts of IFNbeta but are hypersusceptible to viral infection