Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

HRAS

contributors: mct/pgu - updated : 27-03-2019

HGNC name	v-Ha-ras Harvey rat sarcoma viral oncogene homolog
HGNC id	5173

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

COSTS , SMPS1

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   LOH     in bladder cancer and in sporadic invasive breast cancer tumoral somatic mutation       in dedifferentiated liposarcoma and in papillary thyroid cancer with with poor prognosis tumoral       gain of function mutation activating in spermatocytic seminomas tumoral     --over   often associated with tumor aggressiveness in breast cancer

Susceptibility

Variant & Polymorphism repeat	three GGGCCT repeats

Candidate gene
Marker	abnormal methylation of the HRAS gene may be an early event during urocystic tumorigenesis and may be further used as a cancer biomarker in bladder tissue for early diagnosis
Therapy target
	System Type Disorder Pubmed cancer urinary   abnormal methylation of the HRAS gene may be further used as a potential therapeutic target

ANIMAL & CELL MODELS