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FLASH GENE

Symbol

TBL1XR1

contributors: mct - updated : 18-09-2017

HGNC name	transducin (beta)-like 1X-linked receptor 1
HGNC id	29529

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

MRD41

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     recurrent deletions in ETV6-RUNX1 positive acute lymphoblastic leukemia (Parker 2008) tumoral fusion       fusion between TBL1XR1 and TP63, in diffuse large B-cell lymphoma (DLBCL) tumoral     --over   in the nucleus of malignant breast and ovarian cells compared to benign cells

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

mice lacking TBLR1 in adipocytes are defective in fasting-induced lipid mobilization and, when placed on a high-fat-diet, show aggravated adiposity, glucose intolerance, and insulin resistance.