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FLASH GENE

Symbol

ATL1

contributors: mct/shn - updated : 09-09-2013

HGNC name	atlastin GTPase 1
HGNC id	11231

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

SPG3A

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	Depletion of the atlastins or overexpression of dominant-negative forms inhibits tubule interconnections of the endoplasmic reticulum
	mouse cultured cortical neurons, overexpressing ATL1 increased dendrite growth and arborization, while HSP-associated mutant R217Q had no such effects