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FLASH GENE

Symbol

CARD14

contributors: mct - updated : 16-06-2021

HGNC name	caspase recruitment domain family, member 14
HGNC id	16446

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

PRP

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       gain of function after a triggering event that can include epidermal injury, rare gain-of-function mutations in CARD14 initiate a process that includes inflammatory cell recruitment by keratinocytes, a cycle which is the hallmark of psoriasis constitutional germinal mutation     loss of function associated with a severe variant of Atopic dermatitis (AD)

Susceptibility

to Psoriasis (see PSORS2) to inflammatory skin disease to CARD14-associated papulosquamous eruption

Variant & Polymorphism other	rs11652075 (p.Arg820Trp), and c.599G>A (p.Ser200Asn) were associated with psoriasis

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS