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FLASH GENE
Symbol BAALC contributors: mct/npt - updated : 03-10-2015
HGNC name brain and acute leukemia, cytoplasmic
HGNC id 14333
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in leukemic blasts from some patients with acute myeloid leukemia (AML), where high expression is an independent marker of poor prognosis
tumoral     --over  
in glioblastoma, melanoma, and childhood gastrointestinal stroma tumors
tumoral     --over  
is implicated in myeloid leukemogenesis and associated with poor outcome in both acute myeloid leukemia (AML) and acute lymphoblastic leukemia patients
tumoral     --low  
low ABCB1/low BAALC expression identifies a subgroup of intermediate cytogenetic risk AML patients with a remarkably good long-term outcome achieved by chemotherapy alone
Susceptibility to acute myeloid leukemia (AML)
Variant & Polymorphism SNP
  • BAALC overexpression occurs in the presence of the T allele of SNP rs62527607[GT], which creates a binding site for the activating RUNX1 transcription factor in the BAALC promoter region, predisposing to AML
  • Candidate gene
    Marker
  • represents a novel marker of an early progenitor cell common to the myeloid, lymphoid, and erythroid pathways
  • Therapy target
    ANIMAL & CELL MODELS