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FLASH GENE
Symbol WWP1 contributors: mct/npt/pgu - updated : 10-04-2017
HGNC name WW domain containing E3 ubiquitin protein ligase 1
HGNC id 17004
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in some cancer cell lines from the prostate and breast
tumoral     --over  
associated with the estrogen receptor and insulin-like growth factor receptor 1 in breast carcinoma
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerreproductivebreast
promising therapeutic strategy in which developed drugs targeting WWP1 cause activation of LATS1 in suppressing breast cancer cell growth
ANIMAL & CELL MODELS