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FLASH GENE
Symbol SIRT7 contributors: mct - updated : 24-01-2019
HGNC name sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae)
HGNC id 14935
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
overexpressed in human thyroid carcinoma cell lines and tissues
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancer  
is a promising pharmacologic target for epigenetic cancer therapy
ANIMAL & CELL MODELS
  • Sirt7 deficiency in mice induces multisystemic mitochondrial dysfunction, which is reflected by increased blood lactate levels, reduced exercise performance, cardiac dysfunction, hepatic microvesicular steatosis, and age-related hearing loss
  • suppresses ER stress and reverts the fatty liver disease in diet-induced obese mice