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FLASH GENE
Symbol SLC45A2 contributors: mct/npt - updated : 07-06-2017
HGNC name solute carrier family 45, member 2
HGNC id 16472
ASSOCIATED DISORDERS
corresponding disease(s) OCA4
Susceptibility to melanoma
Variant & Polymorphism SNP , other
  • associated with normal variation of pigmentation
  • variants protective for melanoma
  • rare allele L374 significantly increases the
    • possibility of having black hair colour (Branicki 2008)
  • 3 SNP(rs28777, rs35391, and rs16891982) in the MATP gene (SLC45A2) exhibited the strongest crude association with risk of cutaneous malignant melanoma
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS