| Symbol
| NR4A1
| contributors: mct - updated : 02-05-2018
|
| HGNC name
| nuclear receptor subfamily 4, group A, member 1
|
| HGNC id
| 7980
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| constitutional
|
|
| --over
|
|
in a majority of human colon tumors compared to their nontumorous tissues (  | | tumoral
|
|
| --low
|
| |
of NR4A1 and NR4A3 was a common feature in leukemic blasts from human acute myeloid leukemia patients | |
| Susceptibility
|
to tardive dyskinesia (TD) |
| Variant & Polymorphism
SNP
| single nucleotide polymorphism (SNP) marker rs2603751 and rs2701124 showed a nominal association with the risk of TD |
|
|
| 
|
Candidate gene
Marker
Therapy target
|
|
| System | Type | Disorder | Pubmed |
|---|
| cardiovascular | atheroma | | |
| down-regulation of Nur77 by atorvastatin suggests a novel therapy strategy for atherogenesis based on suppression of vascular smooth muscle cells proliferation | | cancer | | | |
| identification of pro-apoptotic agents inducing NR4A expression or acting as agonists suggests that these members could serve as potential targets for cancer therapy | | immunology | inflammatory | | |
| interesting target to treat chronic inflammatory disease | | miscelleaneous | hypertension | | |
| Activation of Nur77 may represent a useful therapeutic strategy for preventing certain cardiovascular diseases, such as atherosclerosis and pulmonary artery hypertension |
| | | |
|
| expression increased in diabetic mice that exhibit elevated gluconeogenesis | |
Nr4a1-deficient mice show increases in CD8 T cell effector responses with improved clearance of Listeria monocytogenes |