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Symbol CORIN contributors: mct/npt - updated : 10-01-2015
HGNC name corin, serine protease
HGNC id 19012
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
in heart failure, plasma corin levels were significantly lower compared with that of healthy controls, but not in those with acute myocardial infarction (Dong 2010)
constitutional       loss of function
with inhibition of natriuretic peptides following exposure to IR may contribute to the development of Radiation-induced heart disease (RIHD) through the acceleration of cellular senescence
constitutional     --low  
in patients with osteoporosis and the reduction was associated with high rates of bone turnover
constitutional     --low  
reduced corin levels in the kidney may reflect the underlying pathology in CKD (chronic kidney disease)
  • to heart failure
  • to preeclampsia
  • Variant & Polymorphism other
  • corin I555(P568) allele is associated with an increased risk for death or heart failure (Rame 2009)
  • two minor alleles (C for rs2271036 and G for rs2271037) were significantly associated to preeclampsia (
  • Candidate gene
  • plasma corin may be used as a biomarker in the diagnosis of heart failure (Dong 2010)
  • promising biomarker of cardiomyopathy and heart failure
  • Marker
  • low serum corin levels may reflect impaired bone homeostasis in patients with osteoporosis
  • Therapy target
  • mice deficient in either Corin or ANP displayed poor trophoblast invasion, impaired spiral artery remodeling and phenocopied human pre-eclampsia
  • corin overexpression significantly prolonged life in mice with dilated cardiomyopathy
  • pregnant corin- or Nppa-deficient mice developed high blood pressure and proteinuria, characteristics of pre-eclampsia (pMID: 22437503)