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FLASH GENE

Symbol

ADAMTS13

contributors: mct/pgu - updated : 23-02-2017

HGNC name	ADAM metallopeptidase with thrombospondin type 1 motif, 13
HGNC id	1366

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

TTPF

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function in preeclampsia constitutional     --low   in the maternal and cord blood were lower in the preeclampsia group than in the control group

Susceptibility

to thrombotic disorders

Variant & Polymorphism SNP , other	ADAMTS13-binding IgG are present in patients with thrombotic thrombocytopenic purpura

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	Adamts13 deficiency in mice does not affect adipose tissue development
	Adamts13 levels are significantly reduced in the plasma of CypB-deficient mice