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FLASH GENE
Symbol ELOVL5 contributors: mct - updated : 16-12-2021
HGNC name ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)
HGNC id 21308
ASSOCIATED DISORDERS
corresponding disease(s) SCA38
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
  fusion      
fused with MLL in acute myelogemous leukemia
tumoral     --over  
in mesenchymal-type gastric cancer cells (GCs), leading to ferroptosis sensitization
Susceptibility
Variant & Polymorphism rs735860 associated with primary open-angle glaucoma (
Candidate gene
Marker
  • epigenetic biomarker for the risk of type 2 diabetes mellitus
  • Therapy target
    ANIMAL & CELL MODELS
  • Elovl5 expression was increased in cellular and mouse models of induced obesity-related diabetes