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FLASH GENE

Symbol

OSBP

contributors: mct - updated : 09-02-2014

HGNC name	oxysterol binding protein
HGNC id	8503

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   enhanced transcription of sterol-regulated proteins, such as low-density lipoprotein (LDL) receptor , whereas it repressed enzymatic activity of ACAT for cholesterol esterification

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	negative regulation of ABCA1 expression by OSBP identifies those receptor as potential therapeutic targets to enhance cholesterol efflux from sensitive tissues

ANIMAL & CELL MODELS