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FLASH GENE
Symbol ANG contributors: mct/shn - updated : 08-09-2011
HGNC name angiogenin, ribonuclease, RNase A family, 5
HGNC id 483
ASSOCIATED DISORDERS
corresponding disease(s) ALS9
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in chronic heart failure (positively associated with age, plasma glucose, insulin, and BNP and negatively correlated with diastolic blood pressure and left ventricular ejection fraction) (Patel 2008)
Susceptibility to amyotrophic lateral sclerosis
Variant & Polymorphism other mutation loss of function in ALS
Candidate gene for ALS
Marker
Therapy target
  • protects against dopaminergic neuronal cell death and suggests its potential as a therapy for Parkinson's disease (
  • ANIMAL & CELL MODELS
  • angiogenin-1 protein is dramatically reduced in this transgenic alpha-synuclein mouse model of Parkinson's disease (