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FLASH GENE
Symbol AKT1 contributors: mct - updated : 18-03-2019
HGNC name v-akt murine thymoma viral oncogene homolog 1
HGNC id 391
ASSOCIATED DISORDERS
corresponding disease(s) PROTS , CWS6
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral       gain of function
amplified in gastric carcinoma
tumoral     --over  
in prostate, breast cancer
constitutional somatic mutation      
somatic activating mutation in Proteus syndrome
constitutional germinal mutation     gain of function
in Cowden and Cowden-like syndrome
tumoral   amplification --over  
in a defined subset of bone and soft tissue tumors, including benign tumors
tumoral   amplification    
amplification of AKT1 and/or AKT2 and high-level polysomy were found in lung carcinomas
Susceptibility to schizophrenia and bipolar disorders
Variant & Polymorphism SNP
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • both Akt1-/- and Igf2-/- mice exhibited decreased placental weight, fetal weight and viability