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Symbol RUNX3 contributors: mct - updated : 24-03-2017
HGNC name runt-related transcription factor 3
HGNC id 10473
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral       loss of function
in gastric cancers advanced stage by deletion or hypermethylation of the promoter or by protein mislocalization and in bile duct and pancreatic carcinoma
tumoral     --over  
in primary and metastatic pancreatic ductal adenocarcinoma
tumoral     --low  
by promoter hypermethylation of the CpG island in colorectal cancer
tumoral   deletion    
in hepatocellular carcinoma
tumoral       loss of function
by hypermethylation in hepatocellular carcinoma
tumoral       loss of function
inactivated by aberrant DNA methylation in 73p 100 of primary bladder tumor specimens and 86 p100 (six of seven) of bladder tumor cell lines
tumoral     --over  
in basal cell carcinomas
tumoral     --low  
in response to hypoxia suppressing RUNX3 (through histone methylation and deacetylation through G9a HMT and HDAC1) in gastric cancer cells at the transcriptional level
tumoral     --low  
epigenetic silencing of RUNX3 gene expression by promoter hypermethylation may play an important role in esophageal squamous cell carcinoma development
tumoral     --over  
promoted cell growth and inhibited apoptosis in head and neck cancer cells (
tumoral       loss of function
loss of RUNX3 expression can enhance the AKT1-mediated signaling pathway and promote the tumorigenesis process in human gastric cancer (
constitutional     --other  
aberrant expression of RUNX3 was associated with the pathogenesis of Immune thrombocytopenia (ITP)
Variant & Polymorphism
Candidate gene promoter methylation and silencing of RUNX3 could be useful prognostic markers for both bladder tumor recurrence and progression
  • RUNX3 and CAMK2N1 hypermethylation are prognostic marker for epithelial ovarian cancer
  • Therapy target
    therapeutic approaches including anti-inflammatory regimens that could diminish the hypoxic insult in gastric epithelial cells should, therefore, be considered and adopted to prevent gastric carcinogenesis and progression
  • Runx3 +/- mice develop lung adenomas spontaneously, providing an animal model for lung tumorigenesis that recapitulate the preneoplastic stage of human lung adenocarcinoma development
  • Runx3-deficient mice develop severe congenital osteopenia