Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

ERBB3

contributors: mct/np/shn/pgu - updated : 20-06-2018

HGNC name	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
HGNC id	3431

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

LCCS2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in a subset of mammary tumors tumoral   amplification --over   amplification and/or overexpression reported in numerous cancers, including prostate, bladder, and breast tumors tumoral     --over   in pilocytic astrocytoma tumoral     --over   strongly associated with tumor progression and poor prognosis of patients with gastric cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive breast therapeutic inhibitors of ERBB3 should be used in combination with HER2 inhibitors and PI3K pathway inhibitors in patients with ERBB2- and PI3K-dependent cancers cancer lung   small inhibitory RNA (siRNA) showing promise as a therapeutic approach to treatment of lung adenocarcinoma cancer skin   targeting ERBB3 activation and downstream genes may provide novel therapeutic interventions for malignant melanoma cancer digestive stomach new prognostic factor and a target of treatment in gastric cancer cancer reproductive breast ERBB3 ablation may be therapeutically effective in tumors where ErbB3 engages PI3K/Akt signaling

ANIMAL & CELL MODELS