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FLASH GENE

Symbol

JAK3

contributors: mct/npt - updated : 02-10-2009

HGNC name	Janus kinase 3
HGNC id	6193

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

SCIDJ

related resource

JAK3base:

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral somatic mutation       in acute megakaryocytic leukemia tumoral somatic mutation       in pediatric acute lymphoblastic leukemia (Mullighan 2009) tumoral somatic mutation     gain of function in adult T-cell leukemia/lymphoma

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	inhibition of JAK signaling is a logical target for therapeutic intervention in JAK mutated ALL (Mullighan 2009)

ANIMAL & CELL MODELS