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FLASH GENE
Symbol TRPV6 contributors: mct/npt - updated : 17-01-2018
HGNC name transient receptor potential cation channel, subfamily V, member 6
HGNC id 14006
ASSOCIATED DISORDERS
corresponding disease(s) TNHP1
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in prostate carcinoma advanced with metastatic lesions
constitutional       gain of function
plays a role in calcium stone formation in certain forms of absorptive hypercalciuria
tumoral     --low  
in esophageal squamous cell carcinoma (ESCC) tissues and cell lines
Susceptibility
Variant & Polymorphism
Candidate gene molecular candidate for apical Ca2+ entry route in renal and intestinal epithelial cells
Marker
  • as a predictive biomarker, TRPV6 plays a Janus-like role in predicting survival of male and female ESCC patients
  • Therapy target
    ANIMAL & CELL MODELS