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FLASH GENE
Symbol HSPE1 contributors: mct - updated : 03-04-2020
HGNC name heat shock 10kDa protein 1 (chaperonin 10)
HGNC id 5269
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved DLFD motif within HSPE1 was critical for targeting NPAT and modulating histone transcription
    • mono polymer homomer , hexamer
    HOMOLOGY
    Homologene
    FAMILY GROES-CHAPERONIN family
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • essential role for mitochondrial protein biogenesis together with HSPD1
  • is an endothelial-derived differentiation factor
  • may be involved in large bowel carcinogenesis
  • is important for S phase progression and cell proliferation )
  • HSPD1/HSPE1 may be implicated in the folding of membrane proteins
  • is reported to be involved in immunomodulation and tumor progression
  • elevated expression of HSPE1 protein inhibits apoptosis and associates with poor prognosis of astrocytoma
  • may likely have a maintenance role in Treg cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HSPE1 is a functional SIRT3 substrate and that, in response to prolonged fasting, SIRT3 levels modulate mitochondrial protein folding
  • HSPE1 is a novel interacting partner of NPAT
  • HSPD1 possesses a GTPase activity and mediates protein folding with HSPE1
    • cell & other
    REGULATION
    induced by by stress
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource Mutations in GroES
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    HSP10-p.Leu73Phe mutation could be the cause or a strong contributing factor for infantile spasms
    constitutional     --low  
    in acute spinal cord injury
    tumoral     --over  
    of HSPE1 protein inhibits apoptosis and associates with poor prognosis of astrocytoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • HSPE1 could be a useful tumor tissue marker for the specific detection of bladder cancer
  • might be a novel independent biomarker for poor prognosis in invasive ductal breast carcinoma (IDBC)
    • Therapy target
    ANIMAL & CELL MODELS