| basic FUNCTION
| comodulator with FB1 of cell death in brain |
|
required for the late-phase of long-term potentiation (LTP) and memory consolidation, and has been implicated in AMPA receptor trafficking |
|
required for multiple forms of synaptic plasticity that depend on its endocytic function including homeostatic scaling |
|
first target of serum response factor that functions at synapses to mediate plasticity  |
|
functions as a spectrin-binding protein, forming a complex that may provide a role at sites of transcriptional regulation within the nucleus |
|
synaptic protein that promotes the internalization of the AMPA subtype of glutamate receptors |
|
PDGF-mediated induction of ARC involved activation of the MAPK/ERK (MEK) pathway |
|
effector immediate-early gene rapidly induced by strong neural activity |
|
functional rolein memory reconsolidation processes in the mammalian brain |
|
required for activity-dependent generation of APP |
|
role in postsynaptic trafficking and processing of APP that appears relevant to the pathogenesis of Alzheimer disease |
|
potentially functioning to increase gamma-secretase in dendritic trafficking endosomes that process APP |
|
critically contributes to weakening synapses by promoting AMPAR endocytosis |
|
essential roles both for the late phase of long-term plasticity and for reduction of surface AMPA-Rs in stimulated neurons |
|
crucial mediator for actin polymerization functions |
