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FLASH GENE
Symbol PCDHB2 contributors: npt - updated : 14/10/2008
HGNC name protocadherin beta 2
HGNC id 8687
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • six extracellular cadherin repeats
  • a transmembrane segment
  • a cytoplasmic tail
  • one PXXP motif
  • a putative SH3 protein-binding site, lacking a constant region
    • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Pcdhb2 protocadherin beta 2
    intraspecies homolog to cadherin
    Homologene
    FAMILY
  • cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
  • protocadherin family
    • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    text integral membrane protein type 1, localized at the synaptic junction
    basic FUNCTION
  • cadherin-related neuronal receptor,putatively involved in the specificity of neuronal connections
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , nervous system
    text
  • playing a putative role in cell-cellinteractions critical in the development of the central nervous system, mediating adhesion in synaptic junctions through locking in process
    • PATHWAY
    metabolism
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • cytoplasmic domain putatively connecting to intermediate filaments
    • cell & other
  • cells expressing in the same protocadherin
    • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS