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FLASH GENE
Symbol TIMM8B contributors: mct - updated : 17-06-2021
HGNC name translocase of inner mitochondrial membrane 8 homolog B (yeast)
HGNC id 11818
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a largely alpha-helical structure
  • one on the N terminal region
  • two cysteine residues
  • one central comprising two cysteine residues
  • a third one and separated from each other by random coil and suggesting a hairpin of helices held together by the cysteine coodination of the Zn2 + ion
    • HOMOLOGY
    interspecies ortholog to yeast S.cerevisiae Tim8p
    ortholog to murine Timm8b
    Homologene
    FAMILY
  • small Tim family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling sensory transduction/hearing
    a component
  • component of the Tm complex
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    by diabetes both in colonic tumor and mucosa
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS