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FLASH GENE
Symbol MYCBP contributors: mct - updated : 17-11-2017
HGNC name c-myc binding protein
HGNC id 7554
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal region involved in all the biologic functions of MYC
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    text
  • mostly expressed in the cytoplasm translocating into the nucleus for c-myc (MYC) expression
  • localizes to the trans-Golgi network (TGN)
  • basic FUNCTION
  • stimulating the activation of the E-box regulated transcription by MYC/MAX
  • playing roles in spermatogenesis
  • may play a central role in regulating the abnormal proliferative characteristics of transformed cells
  • playing an important role in the altered cell proliferation and energy utilization that occur in response to an altered glucose concentration
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • MYCBP forms a complex with GLI and SUFU without HH stimulation but remains inactive
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • c-myc binding, interacting with the N terminal transactivation domain of MYC
  • with MYCBPAP
  • binding to the N-terminal half of AKAP1 in a quaternary complex with C3orf15 and a regulatory subunit (RII) of cAMP-dependent kinase (PKA)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS