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FLASH GENE
Symbol FBXW4 contributors: np/ - updated : 14-06-2006
HGNC name F-box and WD-40 domain protein 4
HGNC id 10847
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one F-box domain
  • four WD repeats
    • HOMOLOGY
    interspecies homolog to Drosophila Shc
    homolog to murine Fbxw4 (92.1pc)
    Homologene
    FAMILY
  • F-box/WD40 protein family
    • CATEGORY adaptor , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in key signaling pathways crucial for normal limb development
  • promoting the ubiquitination and the degradation of some phosphorylated proteins
    • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS development , detoxification
    PATHWAY
    metabolism
    signaling signal transduction
    Ubl conjugation pathway
    a component
  • component of a SCF (SKP1-CULLIN-F-BOX) protein ligase complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to some phosphorylated proteins
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SHFM3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS