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FLASH GENE
Symbol AKAP3 contributors: mct/npt - updated : 01-09-2008
HGNC name a kinase (PRKA) anchor protein 3
HGNC id 373
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • RII binding domain
    • secondary structure an amphipathic helix binding domain
    HOMOLOGY
    Homologene
    FAMILY
  • AKAP110 family
    • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microfilament
    basic FUNCTION
  • a kinase (PRKA regulatory subunit RIIA) anchor protein tethering the enzyme near its physiological substrate
  • may be involved in oocyte recognition
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to SPA17 in spermatozoa (binds the RII binding domain of AKAP3 along the length of the flagella)
    • cell & other
  • sperm-oocyte binding
    • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    correlates with poor prognosis in epithelial ovarian cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS