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FLASH GENE
Symbol CDC42BPB contributors: npt/mct - updated : 24/10/2008
HGNC name CDC42 binding protein kinase beta (DMPK-like)
HGNC id 1738
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • from the N terminus, a serine/threonine kinase domain
  • a cysteine rich motif ressembling those of protein kinase C
  • a pleckstrin homology (PH)
  • a C1 domain with homology to that of the diacylglycerol/phorbol ester-responsive C1 domains reported to bind phorbol ester
  • a C terminal Cdc42 Roc binding domains
    • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • AGC Ser/Thr protein kinase family
  • dystrophia myotonica protein kinase family
  • DMPK subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • CDC42-binding protein kinase beta, phosphorylating non muscle myosin like chain (see MYLK)
    • . prerequisite for the activation of actin-myosin contractility
  • downstream effector of CDC42 in cytoskeletal reorganization
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text cell polarity cytoskeletal reorganisation
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS