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FLASH GENE
Symbol COX6C contributors: mct - updated : 06-02-2018
HGNC name cytochrome c oxidase subunit VIc
HGNC id 2285
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Cox6c
ortholog to rattus cox6c
Homologene
FAMILY cytochrome c oxidase VIc family
CATEGORY enzyme , transport
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
intracellular,cytoplasm,organelle,membrane
basic FUNCTION
  • one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism energetic
    signaling
    a component
  • component of the cytochrome oxidase c (ferrocytochrome c : oxygen oxidoreductase) complex, terminal enzyme in the mitochondrial respiratory chain (oxidative phosphorylation OXPHOS), catalyzing the electron transfer from reduced cytochrome c to molecule oxygen
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NRF1 together with the transcriptional co-activator PPARGC1A stimulates the expression of a broad set of nuclear genes (as COX6C) which are involved in mitochondrial biogenesis and functions
  • DAZAP1 is a negative regulator of pre-mRNA splicing and may control energy production in mitochondria by regulating COX6C expression
    • cell & other
    REGULATION
    activated by thyroid hormones
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource MITOP database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with HMGA2 in uterus leiomyoma t(8;12)(q22;q15)
    tumoral     --over  
    in prostate carcinoma
    constitutional     --low  
    NRF1 and COX6C are down-regulated in Chronic kidney disease (CKD) patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS