| basic FUNCTION
| may be involved in secretory or absorptive processes |
|
non-integral membrane proteins and therefore cannot be chloride channels in their own right |
|
modulating the gastrointestinal phenotype of cystic fibrosis |
|
play critical roles in epithelial secretion, sensory transduction and adaptation, regulation of smooth muscle contraction, control of neuronal and cardiac excitability, and nociception |
|
elevates the single channel conductance of endogenous Ca(2+)-dependent Cl- channels by lowering the energy barriers for ion translocation through the pore  |
|
has an important role in the pathogenesis of respiratory disease such as asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF) |
|
has important functions in cystic fibrosis-related intestinal obstruction |
|
regulate both chloride transport and mucin expression, thus controlling the production of mucus in respiratory and other systems |
|
regulating the transition from proliferation to differentiation in colorectal cancer |
