| basic FUNCTION
| weakly inducer of apoptosis, inducing IL8 |
|
might play a critical role in hepatocellular carcinoma proliferation using both autocrine and paracrine mechanisms, and modulate tumor-related angiogenesis |
|
inhibiting stimulation of the transcriptional activator STAT-1 |
|
inducing p65 nuclear factor (NF)-kappaB association with histone deacetylase 1, repressing cytokine production |
|
suppressing production of IFN-gamma and IL-12 than curtailing the innate response and its transition to adaptive TH1 immunity |
|
may be involved in pathogenesis of hemophagocytic lymphohistiocytosis and is useful as a clinical marker  |
|
implicated as a mediator of chronic inflammatory processes via prolonged activation of the NF-kappaB pathway in several tissues, including the kidney |
|
may regulate cell proliferation, cell death, cell differentiation, angiogenesis and inflammation |
|
multifunctional cytokine known to regulate cellular functions in contexts of injury and disease through its receptor TNFRSF12A |
|
TWEAK/TWEAKR may be important in regulating myocardial structural remodeling and function and may play a role in the pathogenesis of dilated cardiomyopathy |
|
can act in a juxtacrine manner to initiate cellular responses, and this property may be important for its function during physiological wound repair and disease pathogenesis |
|
roles for TNFSF12, BIRC3, and noncanonical NFKB signaling in the regulation of myoblast fusion and highlight a role for cytokine signaling during adult skeletal myogenesis |
