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FLASH GENE
Symbol CTSO contributors: npt/mct - updated : 28/11/2008
HGNC name cathepsin O
HGNC id 2542
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to C.elegans y113g7b.15
Homologene
FAMILY
  • papain family of thiol proteases (peptidase family C1)
  • cysteine proteinase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • cysteine proteinase (endopeptidase), involved in cellular protein degradation and turnover
  • may play an important role in extracellular matrix degradation
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by trans-epoxysuccimyl-L-leucylamino-(4-guanidino) butane (E-64) [enzymatic activity abolished]
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS