basic FUNCTION
| stimulating Rho-dependent signaling pathway |
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playing a role in SEMA4D-plexin-B1 mediating signal transduction |
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role for the exchange factors ARHGEF1 and ARHGEF12 in linking fibronectin signals to downstream RhoA activation |
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acting as a guanine nucleotide exchange factor for RhoA GTPase and may act as a GTPase-activating protein for GNA12, GNA13 |
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candidate tumor suppressor gene |
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is a novel and temporally distinct RhoGEF required for completion of abscission |
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with ARHGEF10, ARHGEF2, ARHGEF12, PLEKHG1 and ARHGEF28, are involved in cyclic-stretch-induced perpendicular reorientation of endothelial cells |