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FLASH GENE
Symbol NDUFS3 contributors: mct - updated : 29-08- 201
HGNC name NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)
HGNC id 7710
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • casein kinase 2 phosphorylation site
  • possible mitochondrial targeting sequence
    • HOMOLOGY
    interspecies homolog to rattus Ndufs3 (85.9 pc)
    homolog to murine Ndufs3 (87.8 pc)
    Homologene
    FAMILY
  • complex I 30 kDa subunit family
    • CATEGORY enzyme , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    text mitochondrial respiratory chain complex I
    basic FUNCTION
  • acting as an NADH ubiquinone oxidoreductase (Q reductase)
  • critical regulator of mitochondrial complex I assembly
  • its expression is a robust indicator of aggressive tumor phenotype in clinical specimens
    • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS electron transport
    text induction of apoptosis (involved in the first step in GZMA-induced cell death, by cleavage)
  • negative regulation of cell growth
  • electron carrier
    • PATHWAY
    metabolism other
    signaling
    oxygen and reactive oxygen species metabolic process
    a component
  • component of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS)
    • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • NAD+
    • protein
    cell & other
    REGULATION
    Other cleaved by GZMA
    ASSOCIATED DISORDERS
    corresponding disease(s) NDUFS3
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in invasive breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • robust indicator of breast cancer progression and invasiveness as well as of hypoxia/necrosis in clinical specimens of invasive ductal carcinoma
    • Therapy target
    ANIMAL & CELL MODELS