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FLASH GENE
Symbol ARID3A contributors: mct - updated : 03-09-2016
HGNC name AT rich interactive domain 3A (BRIGHT-like)
HGNC id 3031
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a functional nuclear localization signal to the N-terminal region of REKLES, a domain conserved within ARID3 paralogues
  • one DNA binding protein containing one AT/rich interaction domain (ARID)
  • one nucleosome assembly protein (NAP) domain
  • AAs within the C terminal REKLES domain containing its nuclear export signal, whose regulation is primarily responsible for its shuttling
    • HOMOLOGY
    interspecies homolog to murine Bright (B cell regulator of IgH transcription)
    homolog to Drosophila dead ringer
    intraspecies paralog to DRIL2
    Homologene
    FAMILY ARID (AT-rich interaction domain) family
    CATEGORY immunity/defense , regulatory , DNA associated , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    text
  • actively shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner
    • basic FUNCTION
  • playing a role in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification
  • regulation of its cellular localization appears to be required for its function
  • nuclear matrix-associated transcription factor that stimulates immunoglobulin heavy chain (IgH) expression and Cyclin E1/E2F-dependent cell cycle progression
  • contributor to accessibility of the IgH enhancer
  • B cell-specific, matrix association (or attachment) region-binding transcriptional regulator of immunoglobulin heavy chain genes and of E2F1-dependent cell cycle progression
  • A+T-rich interaction domain protein, originally discovered in B lymphocyte lineage cells
  • activator of immunoglobulin heavy-chain transcription and proto-oncogene
  • transcriptional regulator required to program both hematopoietic stem cell and lineage-specific differentiation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to promoter proximal site
    RNA
    small molecule
    protein
  • binding partner for ID1 (shares structural similarities with ID1 and recently implicated in TGF-beta1 signaling during embryogenesis
  • B-cell-restricted factor that complexes with Bruton tyrosine kinase (BTK) and its substrate, transcription initiation factor-I (GTF2I), to activate immunoglobulin heavy chain gene transcription in the nucleus
  • transiently interacts with sumoylation enzymes, blocks calcium flux and phosphorylation of BTK and GTF2II and is then discharged from lipid rafts as a Sumo-I-modified form
  • bound to its binding sites in the CDKN1A promoter
  • LIN28B promotes fetal B lymphopoiesis through the transcription factor ARID3A
  • ARID3A is important for IFNA1 expression and show a strong association between ARID3A expression and transcription of genes associated with lupus IFN signatures
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in lungs from patients with idiopathic pulmonary fibrosis and was regulated by TGF-beta1 in human fibroblasts
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    hematopoietic potential of Bright(-/-) mice is markedly reduced